For Patients
Live healthier, longer.
Your blood carries the key signals that influence how your body repairs, regenerates, and ages. Therapeutic Plasma Exchange helps clear inflammatory substances that can cause disease and accelerated aging, creating a cleaner internal environment to help your body perform and repair at its best.
Why choose TPE?
TPE has been clinically recognized for its ability to support key systems that influence how we age and recover. Many patients describe a renewed sense of focus, stamina, and well-being following treatment. TPE benefits include:
- Reduce chronic inflammation linked to fatigue, pain, and cognitive fog
- Support longevity by maintaining healthy circulation and immune balance
- Enhance recovery and performance
- Boost cognitive and physical function
- Complement other therapies for autoimmune, metabolic, and neurodegenerative conditions
Hear about the change patients feel after TPE
Is TPE right for you?
TPE is used across a range of health contexts. People seek treatment for different reasons.
Chronic inflammation
Autoimmune conditions
Neurological conditions
Post-viral symptoms
Patient-first care. Proven safety.
TPE has been used safely in medical practice for over 50 years. With Circulate Health, every treatment is delivered by specialized apheresis nurses who stay with you from start to finish. FDA-cleared equipment, standardized protocols, and continuous monitoring mean your comfort and safety are never an afterthought.
What to expect from your treatment
Each TPE session lasts about two to three hours in a comfortable clinical setting. A Circulate specialized apheresis nurse monitors you throughout, ensuring safety and comfort at every step. Most patients read, rest, or work during treatment and return to normal activities the same day.
What patients notice
Many patients describe feeling clearer, lighter, and more energized. Results vary based on indication and individual health, but improvements are often noticed after the first few sessions.
“Watching all my bloodwork numbers move into or towards the green gives me a lot of confidence in what I’m doing with TPE.”
– Kevin MacDonald, 63-year-old longevity patient
90% of patients report high satisfaction with their TPE experience.*
*Circulate post-procedure survey
Where We Are
California: Los Angeles, La Jolla, San Francisco, Chatsworth, Newport Beach Florida: Miami, West Palm Beach, Boca Raton New York New York City
Texas: Dallas, Austin Utah: Park City Washington: Seattle, Belleuve
Coming soon: Myrtle Beach, South Carolina | Denver, Colorado | Atlanta, Georgia | Chicago, Illinois | Salt Lake City, Utah | Bahamas
Common questions about TPE
What is Therapeutic Plasma Exchange?
Your blood carries more than oxygen and nutrients. It carries signals—proteins, antibodies, and byproducts that influence how your body functions, recovers, and ages. Over time, some of these can build up faster than your body clears them. Therapeutic Plasma Exchange, or TPE, separates and replaces your plasma, helping reduce that burden and creating a cleaner environment for your body to work from.
Is TPE safe?
Yes. TPE has been used safely in hospitals and specialty clinics for over 50 years. Most patients experience no complications. Mild effects like temporary lightheadedness due to mild drops in blood pressure, tingling sensations or cold sensation, mild stomach upset, or fatigue can occur and typically resolve quickly. Each treatment is continuously monitored by a trained apheresis nurse to ensure comfort and safety.
What does therapeutic plasma exchange cost?
How many treatments will I need?
Your provider will work with you to design a personalized treatment plan based on your condition and goals. Most patients benefit from a series of TPE sessions—results tend to build over time. Some complete an initial round, while others continue with maintenance sessions to sustain improvements.
What should I expect after treatment?
On the day of your treatment, you should avoid strenuous activity and take it easy for the rest of the day. Most people can return to normal activities within 24 hours. Drink fluids, eat a balanced meal, and rest if you feel tired. Some providers recommend post-treatment lab work to track your progress — your care team will guide you.
Does insurance cover TPE?
Coverage varies by indication and insurance provider. Many patients receive TPE as a self-pay service through longevity or concierge programs. However, Circulate can provide a superbill upon request for patients who wish to submit for potential reimbursement through their insurance plan.
Interested in TPE?
Whether you’re exploring treatment for longevity, chronic conditions, or recovery, we’re here to help you take the next step.