Indications and Protocols
Therapeutic plasma exchange is used across a range of immune, neurological, metabolic, and longevity-focused conditions. Whether you’re a patient exploring treatment options or a provider evaluating how to bring TPE to your clinic, understanding the evidence behind each indication is the first step.
Who TPE supports
TPE is an established therapy across a range of conditions. Providers evaluate clinical appropriateness based on patient history, goals of care, and available evidence.
- Alzheimer’s Disease
- Alzheimer’s Risk
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
- Complex Regional Pain Syndrome (CRPS)
- Longevity Promotion
- Lyme Disease
- Mercury Ingestion
- Microplastics Burden/Removal
- Mold Toxicity
- Myalgic Encephalomyelitis -Chronic Fatigue Syndrome (ME/CFS)
- PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders)
- Paraneoplastic Neurological Syndromes
- Post-Covid Condition (Long Covid)
- Post-exertional Malaise (PEM)
- Postural Orthostatic Tachycardia Syndrome* (POTS)
- Wellness Optimization
A consistent standard of care
Circulate delivers Therapeutic Plasma Exchange through standardized protocols and written operating procedures that guide how care is delivered, monitored, and adjusted over time. No matter the indication, treatments follow the same high standard for safety, nursing expertise, and patient experience.
Indication-specific protocols
Every Circulate protocol is standardized and evidence-informed, with treatment cadence, monitoring, and follow-up built in, so patients know what to expect and providers can deliver care with confidence.