For Clinics
Offer Therapeutic Plasma Exchange with confidence.
Circulate Health partners with clinics to deliver therapeutic plasma exchange (TPE) as a turnkey, fully supported clinical service. Expert nurses. Standardized care plans. Measurable outcomes. You focus on your patients. We handle the complexity.
The smartest way to add TPE to your practice.
Circulate makes it easy to offer therapeutic plasma exchange without the operational lift. We bring the clinical infrastructure so you can expand your offerings and meet growing patient demand for advanced longevity care.
- Expert apheresis nurses, fully supported by Circulate’s medical team
- FDA-cleared equipment and standardized protocols
- Quality assurance and supply management
- Dedicated support from the Circulate Clinic Success team
Built on decades of science.
TPE has been used in medical practice for over 50 years and is recognized by the American Society for Apheresis (AFSA) for conditions affecting the immune, neurological, and metabolic systems. Circulate is advancing the evidence through standardized protocols, outcomes tracking, and ongoing clinical research.
The Circulate Trial Demonstrated
2.6 years: average biological age reduction after six TPE sessions.*
*Source: Aging Cell (2025). Study by Fuentealba et al.
Protocols tailored to each indication
Circulate has developed proprietary clinical protocols that guide how TPE is delivered based on the reason for treatment. Every protocol is built around conditions where outcomes can be measured and tracked.
Chronic inflammation
Autoimmune conditions
Neurological conditions
Post-viral symptoms
What TPE clinic partners are saying
“Circulate…is seamless, efficient, and a true game-changer for patients who need meaningful results. Their program is truly turnkey—clear protocols, excellent training, and a level of operational support that makes implementation seamless.”
– Elizabeth Tringali, PA-C, owner, Tringali Vibrant Health
90% of patients report high satisfaction with their TPE experience.*
*Circulate post-procedure survey
More than TPE delivery
Partnering with Circulate means access to a full ecosystem of support designed to elevate your clinic and improve patient outcomes with the addition of TPE.
- Diagnostic testing alignment & preferred pricing
- Clinic enablement playbooks & SOPs
- Marketing & positioning toolkits
- Clinical protocol library
- Clinical study & data participation
- Circulate360 platform access
Common questions from providers
What should providers consider before prescribing TPE?
Comprehensive evaluation: Review the patient’s underlying diagnosis, consideration of comorbidities, goals of care, and contraindications.
Medication management: Certain medications (e.g., immunosuppressants, biologics, blood pressure medications, and blood thinners) may require timing adjustments around treatment sessions.
Baseline labs: Complete Blood Count (CBC), Comprehensive Metabolic Panel (CMP), coagulation profile, and relevant disease-specific markers should be reviewed prior to initiation.
Hydration and vascular access: Adequate venous access and pre-procedure hydration are key for optimal outcomes.
How long does a TPE procedure take?
Clinics should plan for a 3–4 hour room block per patient visit. Two patients per day per room is a comfortable planning baseline.
What are the clinical indications for TPE?
TPE is an established therapy across a range of conditions, including:
- Autoimmune disorders
- Metabolic and hematologic disorders
- Neurological and renal disorders
- Longevity and prevention medicine
- Providers should evaluate the evidence base and clinical appropriateness for each indication.
How often should patients receive TPE?
Frequency depends on indication and clinical response, from several times per week for acute states to biweekly or quarterly for maintenance. Diagnostics like lab work and symptom tracking help measure progress and guide adjustments. Circulate’s clinical team works directly with referring providers to tailor treatment plans based on patient needs and measurable outcomes.
What kind of outcomes can be expected?
Patients frequently report measurable improvements in energy, cognitive clarity, and overall vitality. Objective data may include reduced inflammatory biomarkers, improved immune balance, and better metabolic parameters. Early studies suggest potential benefits for supporting healthy aging and extending healthspan through improved biological function.
Additional benefits include:
- Help minimize inflammation to mitigate biological aging
- Boost mental clarity, improve memory, and enhance cognitive function
- Promote heart health and improve circulation
- Assist in the removal of toxins and support the body's natural detoxification process
- Strengthen the immune system to feel well and stay well
- Revitalize and restore overall health and wellness
- Support healthy lipid levels by removing harmful cholesterol
How can I refer a patient or learn more?
Providers can contact our medical team directly for referral guidelines, eligibility criteria, and shared care coordination by sending an email to: medical@circulate.health.
Additional provider and patient education materials are available on circulatehealth.com.
Interested in becoming a TPE partner clinic?
Learn how your clinic can offer therapeutic plasma exchange with full clinical and operational support.